1. Prioritising in-house research to focus on the ten most common causes of death and disease in South Africa; 2. Increasing extramural funding to universities and medical schools in order to rebuild their health and research; 3. Creating new funding approaches for the development of new drugs, vaccines and diagnostic tests; 4. Improving the efficiency and effectiveness of the MRC's administrative systems; 5. Improving peer-review and the quality of MRC research; 6. Improving the MRC's laboratory and space utilisation; and 7. Improving research support functions like medical journals.